What is Tesofensine?
Peptide Center
Tesofensine is a triple monoamine reuptake inhibitor (MRI) originally developed as a treatment for neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. However, clinical trials revealed that it had a powerful appetite-suppressing and weight-loss effect, leading to its investigation as an anti-obesity drug.
How Does Tesofensine Work?
Tesofensine works by inhibiting the reuptake of three key neurotransmitters in the brain:
• Dopamine – Enhances motivation, reward response, and energy levels.
• Serotonin – Regulates mood, appetite, and satiety.
• Norepinephrine – Boosts metabolism and fat-burning.
By increasing these neurotransmitter levels, Tesofensine reduces appetite, enhances satiety, and accelerates fat metabolism, making it highly effective for weight loss.
Benefits of Tesofensine
Potential Weight Loss – Studies show greater weight loss than most current obesity medications.
Appetite Suppression – Reduces cravings and calorie intake.
Increased Metabolism – Enhances fat-burning and energy expenditure.
Mood & Cognitive Benefits – Due to its effect on dopamine and serotonin, it may improve mood and mental clarity.
Potential for Fat Loss Without Muscle Loss – Helps preserve lean muscle mass during weight reduction.
Tesofensine vs. Other Weight Loss Medications
Compared to drugs like Semaglutide (GLP-1 agonists) and Phentermine, Tesofensine works through a unique mechanism focused on neurotransmitters, making it a powerful appetite suppressant.
Since Tesofensine affects dopamine, serotonin, and norepinephrine, it has stimulant-like properties, which require careful monitoring.
Who Uses Tesofensine?
• Individuals with obesity or weight loss resistance
• People looking for a powerful appetite suppressant
• Those seeking an alternative to GLP-1 agonists like Semaglutide
When do you take Tesofensine?
Tesofensine is typically taken once daily, preferably in the morning. This timing is recommended because of its long half-life (about 24 hours) and its potential stimulant-like effects, which could cause insomnia or restlessness if taken too late in the day.
**Optimal Timing for Tesofensine
• Morning (with or without food) – Most users take it in the morning to avoid sleep disturbances.
• Before or after breakfast – Taking it with food may help reduce nausea in some individuals.
• Consistent daily schedule – Keeping a regular routine ensures stable blood levels of the drug.